Proliferation and benevolence—A framework for dissecting the mechanisms of microbial virulence and health promotion

Research output: Contribution to journalArticle

Abstract

Key topics in the study of host–microbe interactions—such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria—would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework for the integrated study of host–microbe interactions. This framework partitions the health effects of microbes and the effector molecules they produce into components with different evolutionary implications. It thereby facilitates the prediction of evolutionary responses to inhibition and exploitation of specific molecular mechanisms.

Details

Authors
Organisations
External organisations
  • Georgia Institute of Technology
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmaceutical Sciences
  • Bioinformatics and Systems Biology

Keywords

  • commensal, evolution, infection, probiotic, resistance, symbiosis, tolerance, virulence, virulence factor
Original languageEnglish
Pages (from-to)879-888
Number of pages10
JournalEvolutionary Applications
Volume13
Issue number5
Early online date2020 Mar 14
Publication statusPublished - 2020 May
Publication categoryResearch
Peer-reviewedYes