Prophylactic treatment in Sweden - Overtreatment or optimal model?

Research output: Contribution to journalArticle


At the haemophilia centre in Malmo, Sweden, regular prophylactic treatment is begun at 1-1 1/4 years of age, before the onset of joint bleeds. The dose and dose interval are optimised by means of pharmacokinetic studies to determine the individual patient's FVIII or IX metabolism, the goal of maintaining a level > 1% of normal being taken as a guideline which experience has shown to yield satisfactory control of bleeding diathesis. An optimal model for prophylactic treatment needs to be applicable to haemophiliacs and acceptable to health authorities in a majority of the countries in the world. To fulfill these criteria, the Swedish model, which has been shown to yield most satisfactory outcome, can hopefully be further refined in the future. Were continuous infusion, using a recombinate concentrate with a prolonged half-life, technically feasible and socially acceptable to the child, we would probably have attained the optimal model of prophylactic treatment.


External organisations
  • Skåne University Hospital
Research areas and keywords


  • Factor IX, Factor VIII, Haemophilia A, Haemophilia B, Prophylaxis, blood clotting factor, blood clotting factor 8, blood clotting factor 9, conference paper, continuous infusion, drug half life, hemarthrosis, hemophilia, human, metabolism, practice guideline, priority journal, prophylaxis, Sweden
Original languageEnglish
Pages (from-to)409-412
Issue number4
Publication statusPublished - 1998 Nov 25
Publication categoryResearch