Prophylaxis Escalation in Severe von Willebrand Disease: A Prospective Study from the von Willebrand Disease Prophylaxis Network.

Research output: Contribution to journalArticle


Treatment of mucosal bleeding (epistaxis, gastrointestinal and menorrhagia) and joint bleeding remains problematic in clinically severe von Willebrand Disease (VWD). Patients are often unresponsive to treatment (e.g. desmopressin or antifibrinolytic therapy) and may require von Willebrand (VW) factor replacement therapy. There are little data on the use of prophylaxis in VWD and none applied in a prospective, treatment escalation design.


  • T Abshire
  • J Cox-Gill
  • C L Kempton
  • F W G Leebeek
  • M Carcao
  • P Kouides
  • S Donfield
  • Erik Berntorp
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)1585-1589
JournalJournal of Thrombosis and Haemostasis
Issue number9
Publication statusPublished - 2015
Publication categoryResearch