Prostaglandin E(2) and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: No impact on survival of seizure-generated neurons.

Research output: Contribution to journalArticle

Abstract

Partial and generalized status epilepticus (pSE and gSE) trigger the same level of progenitor cell proliferation in adult dentate gyrus, but survival of new neurons is poor after gSE. Here, we show markedly elevated levels of prostaglandin E-2 (PGE(2)) and brain-derived neurotrophic factor (BDNF) in rat hippocampal formation at 7 days following pSE but not gSE. Administration of the cyclooxygenase (COX) inhibitor flurbiprofen for 1 week, starting at day 8 post-SE, abated PGE(2) and decreased BDNF levels, but did not affect survival of new neurons a weeks later. Thus, high PGE(2) and BDNF levels induced by pSE are probably not of major importance for survival of new neurons during the first days after formation. We propose that they modulate other aspects of synaptic and cellular plasticity, and thereby may influence epileptogenesis.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • status epilepticus, flurbiprofen, neurogenesis, isoprostanes, EP3, EP2, neurotrophic factor (BDNF), brain-derived, prostaglandin E-2 (PGE(2)), cyclooxygenase-2 (COX-2)
Original languageEnglish
Pages (from-to)23-35
JournalNeurobiology of Disease
Volume23
Issue number1
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes

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Iosif, R., 2008, Department of Clinical Sciences, Lund University. 116 p.

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