Protein adsorption of poly(ether urethane) surfaces modified by amphiphilic and hydrophilic polymers

Research output: Contribution to journalArticle

Abstract

A commercial biomedical poly(ether urethane), Pellethane 2363-80AE, was surface modified through the use of amphiphilic polymeric additives, and through surface grafting with poly(ethylene glycol), PEG. Two different amphiphilic polymers, Polymer C and Pluronic PE9400, were used as additives. Polymer C, a segmented polyurethane, was prepared from PEG1500, 4,4'-diphenylmethane diisocyanate and a C-16-C18 monoglyceride chain extender. Pluronic PE9400 is a propylene oxide-ethylene oxide tri-block co-polymer obtained from BASF. Adsorption of human albumin and fibrinogen to the modified surfaces was studied by means of radiolabelled proteins. By contact angle measurements and X-ray photoelectron spectra the amphiphilic polymers were shown to accumulate at the polyurethane surfaces. Adsorption of fibrinogen, in particular, was significantly reduced by the amphiphilic additives to levels similar to those obtained for Pellethane surfaces grafted with PEG 20000. In vitro clotting times for citrate-buffered blood in contact with the amphiphilic surfaces increased as compared with the unmodified ones.

Details

Authors
  • Bengt Wesslén
  • Maria Kober
  • Christina Freij-Larsson
  • Åsa Ljungh
  • Marianne Paulsson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Bioengineering Equipment

Keywords

  • amphiphilic polymers, surface modification, Protein adsorption, polymer grafting, poly(ethylene glycol), polyurethane
Original languageEnglish
Pages (from-to)278-284
JournalBiomaterials
Volume15
Issue number4
Publication statusPublished - 1994
Publication categoryResearch
Peer-reviewedYes

Related research output

Freij-Larsson, C., 1996, Center for Chemistry and Chemical Engineering. 52 p.

Research output: ThesisDoctoral Thesis (compilation)

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