Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin.

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title = "Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin.",
abstract = "Protein E (PE) of nontypeable Haemophilus influenzae (NTHi) is involved in adhesion and activation of epithelial cells. A total of 186 clinical NTHi isolates, encapsulated H. influenzae, and culture collection strains were analyzed. PE was highly conserved in both NTHi and encapsulated H. influenzae (96.9{\%}-100{\%} identity without the signal peptide). PE also existed in other members of the genus Pasteurellaceae. The epithelial cell binding region (amino acids 84-108) was completely conserved. Phylogenetic analysis of the pe sequence separated Haemophilus species into 2 separate clusters. Importantly, PE was expressed in 98.4{\%} of all NTHi (126 isolates) independently of the growth phase.",
author = "Birendra Singh and Marta Brant and Mogens Kilian and Bj{\"o}rn Hallstr{\"o}m and Kristian Riesbeck",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Cell and Organism Biology (Closed 2011.) (011002100), Clinical Microbiology, Malm{\"o} (013011000)",
year = "2010",
doi = "10.1086/649782",
language = "English",
volume = "201",
pages = "414--419",
journal = "Journal of Infectious Diseases",
issn = "1537-6613",
publisher = "Oxford University Press",