Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin.

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Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin. / Singh, Birendra; Brant, Marta; Kilian, Mogens; Hallström, Björn; Riesbeck, Kristian.

In: Journal of Infectious Diseases, Vol. 201, 2010, p. 414-419.

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Singh, Birendra ; Brant, Marta ; Kilian, Mogens ; Hallström, Björn ; Riesbeck, Kristian. / Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin. In: Journal of Infectious Diseases. 2010 ; Vol. 201. pp. 414-419.

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TY - JOUR

T1 - Protein E of Haemophilus influenzae Is a Ubiquitous Highly Conserved Adhesin.

AU - Singh, Birendra

AU - Brant, Marta

AU - Kilian, Mogens

AU - Hallström, Björn

AU - Riesbeck, Kristian

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Cell and Organism Biology (Closed 2011.) (011002100), Clinical Microbiology, Malmö (013011000)

PY - 2010

Y1 - 2010

N2 - Protein E (PE) of nontypeable Haemophilus influenzae (NTHi) is involved in adhesion and activation of epithelial cells. A total of 186 clinical NTHi isolates, encapsulated H. influenzae, and culture collection strains were analyzed. PE was highly conserved in both NTHi and encapsulated H. influenzae (96.9%-100% identity without the signal peptide). PE also existed in other members of the genus Pasteurellaceae. The epithelial cell binding region (amino acids 84-108) was completely conserved. Phylogenetic analysis of the pe sequence separated Haemophilus species into 2 separate clusters. Importantly, PE was expressed in 98.4% of all NTHi (126 isolates) independently of the growth phase.

AB - Protein E (PE) of nontypeable Haemophilus influenzae (NTHi) is involved in adhesion and activation of epithelial cells. A total of 186 clinical NTHi isolates, encapsulated H. influenzae, and culture collection strains were analyzed. PE was highly conserved in both NTHi and encapsulated H. influenzae (96.9%-100% identity without the signal peptide). PE also existed in other members of the genus Pasteurellaceae. The epithelial cell binding region (amino acids 84-108) was completely conserved. Phylogenetic analysis of the pe sequence separated Haemophilus species into 2 separate clusters. Importantly, PE was expressed in 98.4% of all NTHi (126 isolates) independently of the growth phase.

U2 - 10.1086/649782

DO - 10.1086/649782

M3 - Article

VL - 201

SP - 414

EP - 419

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 1537-6613

ER -