Proteoglycan epitope in synovial fluid in gonarthrosis: 28 cases of tibial osteotomy studied prospectively for 2 years

Research output: Contribution to journalArticle


High tibial osteotomy was performed for medial gonarthrosis in 28 patients. Preoperatively, and at 3, 12, and 24 months after surgery, clinical and radiographic examinations were made, and joint-fluid samples were aspirated. Arthroscopy was performed preoperatively and at 24 months. Immunoassay of proteoglycan epitope in joint fluid showed an increase in concentration at all times as compared with a reference population with normal knee joints. An increase in both the concentration and the total amount of proteoglycan epitope in joint fluid was noted at 3 months postoperatively with a return to preoperative values at later times. Regrowth of fibrocartilage did not correlate with proteoglycan epitope data


External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Rheumatology and Autoimmunity
  • Orthopedics


  • Knee joint, gonarthrosis
Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalActa Orthopaedica
Issue number2
Publication statusPublished - 1991
Publication categoryResearch