Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

Research output: Contribution to journalArticle

Abstract

Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.

Details

Authors
  • Annette Dalrymple
  • Edward J. Wild
  • Richard Joubert
  • Kirupa Sathasivam
  • Maria Bjorkqvist
  • Åsa Petersén
  • Graham S. Jackson
  • Jeremy D. Isaacs
  • Mark Kristiansen
  • Gillian P. Bates
  • Blair R. Leavitt
  • Geoff Keir
  • Malcolm Ward
  • Sarah J. Tabrizi
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Basic Medicine

Keywords

  • electrophoresis, 2D, proteomics, neuroinflammation, Huntington's disease, plasma, LC/MS/MS, MALDI-TOF, ELISA, biomarkers
Original languageEnglish
Pages (from-to)2833-2840
JournalJournal of Proteome Research
Volume6
Issue number7
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes