Radiation treatment monitoring using multimodal functional imaging: PET/CT ((18)F-Fluoromisonidazole & (18)F-Fluorocholine) and DCE-US.

Research output: Contribution to journalArticle

Abstract

This study aims to assess the effect of radiation treatment on the tumour vasculature and its downstream effects on hypoxia and choline metabolism using a multimodal approach in the murine prostate tumour model CWR22. Functional parameters derived from Positron Emission Tomography (PET)/Computer Tomography (CT) with (18)F-Fluoromisonidazole ((18)F-FMISO) and (18)F-Fluorocholine ((18)F-FCH) as well as Dynamic Contrast-Enhanced Ultrasound (DCE-US) were employed to determine the relationship between metabolic parameters and microvascular parameters that reflect the tumour microenvironment. Immunohistochemical analysis was employed for validation.

Details

Authors
  • Natalia Arteaga-Marrero
  • Cecilie Brekke Rygh
  • Jose F Mainou-Gomez
  • Tom C H Adamsen
  • Nataliya Lutay
  • Rolf K Reed
  • Dag R Olsen
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Article number383
JournalJournal of Translational Medicine
Volume13
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes