Radiofrequency catheter ablation maintains its efficacy better than antiarrhythmic medication in patients with paroxysmal atrial fibrillation: On-treatment analysis of the randomized controlled MANTRA-PAF trial.

Research output: Contribution to journalArticle


The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation (MANTRA-PAF) is a randomized trial comparing radiofrequency catheter ablation (RFA) to antiarrhythmic drugs (AADs) as first-line treatment of paroxysmal atrial fibrillation (PAF). In order to eliminate the clouding effect of crossover we performed an on-treatment analysis of the data.


  • M J Pekka Raatikainen
  • Antti Hakalahti
  • Paavo Uusimaa
  • Jens Cosedis Nielsen
  • Arne Johannessen
  • Gerhard Hindricks
  • Håkan Walfridsson
  • Steen Pehrson
  • Anders Englund
  • Juha Hartikainen
  • Ole Kongstad Rasmussen
  • Leif Spange Mortensen
  • Peter Steen Hansen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)108-114
JournalInternational Journal of Cardiology
Publication statusPublished - 2015
Publication categoryResearch