Radio-iodobenzylguanidine scintigraphy of neuroblastoma: conflicting results, when compared with standard investigations

Research output: Contribution to journalArticle

Abstract

Seventy-one patients with neuroblastoma (NB) and 25 patients with other neoplastic or nonneoplastic diseases were studied with MIBG scintigraphy. Sensitivity and specificity at diagnosis were 94% and 88%, respectively. Of 52 patients with NB studied during follow-up, 14 had on one or several occasions conflicting results, when the findings at MIBG scintigraphy were compared to standard investigations (SI: CT scan, bone scan, x-ray, and ultrasound). The correlation of MIBG scintigraphy and SI to clinical outcome were in these 14 patients not significantly different. Adding VMA-excretion measurements did not significantly improve the predictive value of MIBG scintigraphy or SI. Patients with tumor-suspected lesions only at MIBG scintigraphy should be followed closely and the nature of the lesions should be explored through biopsy.

Details

Authors
  • Kjeld Schmiegelow
  • Martti A Simes
  • Lone Agertoft
  • Gunilla Berglund
  • Ingebjörn Storm-Mathisen
  • Michael Andreassen
  • Toivo T Salmi
  • Randi Nygard
  • Thomas Wiebe
  • Anders Kreuger
  • Salah Hayder
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics

Keywords

  • MIBG scintigraphy, sensitivity, specificity, predictive value
Original languageEnglish
Pages (from-to)126-130
JournalMedical and Pediatric Oncology
Volume17
Issue number2
Publication statusPublished - 1989
Publication categoryResearch
Peer-reviewedYes