Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs

Research output: Contribution to journalArticle


Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels.


  • Márcio Machado Costa
  • Raqueli Teresinha França
  • Aleksandro Schafer Da Silva
  • Carlos Breno Paim
  • Francine Paim
  • Carlos Henrique do Amaral
  • Guilherme Lopes Dornelles
  • João Paulo Monteiro Carvalho Mori da Cunha
  • João Fabio Soares
  • Marcelo Bahia Labruna
  • Cinthia Melazzo Andrade Mazzanti
  • Silvia Gonzalez Monteiro
  • Sonia Terezinha Dos Anjos Lopes
External organisations
  • Federal University of Santa Maria
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area


  • Acute Disease, Alanine Transaminase/blood, Animals, Aspartate Aminotransferases/blood, Creatine Kinase/blood, Dog Diseases/blood, Dogs, Female, Protozoan Infections, Animal/blood
Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalRevista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria
Issue number3
Publication statusPublished - 2012 Oct 17
Publication categoryResearch
Externally publishedYes