Rapid and efficient induction of functional astrocytes from human pluripotent stem cells

Research output: Contribution to journalArticle

Abstract

The derivation of astrocytes from human pluripotent stem cells is currently slow and inefficient. We demonstrate that overexpression of the transcription factors SOX9 and NFIB in human pluripotent stem cells rapidly and efficiently yields homogeneous populations of induced astrocytes. In our study these cells exhibited molecular and functional properties resembling those of adult human astrocytes and were deemed suitable for disease modeling. Our method provides new possibilities for the study of human astrocytes in health and disease.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology
Original languageEnglish
Pages (from-to)693-696
Number of pages4
JournalNature Methods
Volume15
Issue number9
Publication statusPublished - 2018 Aug 20
Publication categoryResearch
Peer-reviewedYes