Rapid resolution of EPO-induced pure red cell aplasia after a course of immunoadsorption therapy using protein a columns

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Pure red cell aplasia (PRCA) is a rare, but important, complication of erythropoietin (EPO) replacement therapy in patients with renal disease. There is no consensus about the best way to treat this condition; however, recent reports indicated that immunosuppressive therapy is beneficial. We report a patient with EPO-induced PRCA treated with a regimen initially designed for antifactor VIII antibodies in patients with hemophilia. This regimen consists of immunoadsorption therapy using protein A columns, followed by oral prednisolone and single bolus infusions of intravenous immunoglobulin G and cyclophosphamide. Shortly after the course, a swift and rapid increase in reticulocyte count was evident; the patient became transfusion independent and has remained so during 2 years of follow-up. By means of this report, we wish to encourage others to consider this option when first-line treatments fail.


Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology


  • immunoadsorption, protein A, erythropoietin (EPO), pure red cell aplasia
Original languageEnglish
Pages (from-to)E97-E99
JournalAmerican Journal of Kidney Diseases
Issue number6
Publication statusPublished - 2005
Publication categoryResearch