Rare and low-frequency coding variants alter human adult height

Research output: Contribution to journalArticle

Abstract

Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.

Details

Authors
  • Eirini Marouli
  • Mariaelisa Graff
  • Carolina Medina-Gomez
  • Ken Sin Lo
  • Andrew R Wood
  • Troels R. Kjaer
  • Rebecca S. Fine
  • Yingchang Lu
  • Claudia Schurmann
  • Heather M Highland
  • Sina Rüeger
  • Gudmar Thorleifsson
  • Anne E Justice
  • David Lamparter
  • Kathleen E. Stirrups
  • Valérie Turcot
  • Kristin L. Young
  • Thomas W Winkler
  • Tõnu Esko
  • Tugce Karaderi
  • Adam E. Locke
  • Nicholas G D Masca
  • Maggie C. Y. Ng
  • Poorva Mudgal
  • Manuel A Rivas
  • Sailaja Vedantam
  • Anubha Mahajan
  • Xiuqing Guo
  • Goncalo Abecasis
  • Katja K Aben
  • Linda S. Adair
  • Dewan S. Alam
  • Eva Albrecht
  • Kristine H. Allin
  • Matthew Allison
  • Philippe Amouyel
  • Emil V. Appel
  • Dominique Arveiler
  • Folkert W Asselbergs
  • Paul L. Auer
  • Beverley Balkau
  • Bernhard Banas
  • Lia E Bang
  • Marianne Benn
  • Sven Bergmann
  • Lawrence F. Bielak
  • Matthias Blüher
  • Paul W. Franks
  • Frida Renström
  • Tibor V. Varga
  • MAGIC Investigators
  • The EPIC-InterAct Consortium
  • EPIC-CVD Consortium
  • CHD Exome+ Consortium
  • ExomeBP Consortium
  • T2D-Genes Consortium
  • GoT2D Genes Consortium
  • Global Lipids Genetics Consortium
  • ReproGen Consortium
Organisations
External organisations
  • Montreal Heart Institute
  • Boston Children's Hospital
  • University of Lausanne
  • University of Regensburg
  • Centre for Control of Chronic Diseases (CCCD)
  • San Diego State University
  • Lille 2 University
  • University Hospital Of Strasbourg
  • University College London
  • University of Wisconsin-Milwaukee
  • Centre for Research in Epidemiology and Population Health (CESP)
  • Queen Mary University
  • North Carolina State University
  • Erasmus University Medical Center
  • University of Exeter
  • Aarhus University
  • Icahn School of Medicine at Mount Sinai
  • University of Texas
  • Swiss Institute of Bioinformatics
  • deCODE Genetics
  • University of Cambridge
  • Tartu University Hospital
  • University of Oxford
  • University of Washington
  • Glenfield Hospital
  • Wake Forest University
  • Harbor–UCLA Medical Center
  • Michigan Technological University
  • Radboud University Medical Center
  • Helmholtz Zentrum München
  • Hagedorn Research Institute, Copenhagen University
  • University Hospital Regensburg
  • Copenhagen University Hospital
  • Leipzig University
  • Harvard University
  • Umeå University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
Original languageEnglish
Pages (from-to)186-190
JournalNature
Volume542
Issue number7640
Publication statusPublished - 2017 Feb 9
Publication categoryResearch
Peer-reviewedYes