Receptor binding mimetics: a novel molecularly imprinted polymer

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Abstract

A novel molecularly imprinted polymer was prepared by copolymerization of trimethylolpropane trimethacrylate (1) and methacrylic acid (3) in the presence of a dipeptide acting as the template. The recognition capability of the synthetic receptor-like binding sites produced in the polymer network for the peptide was demonstrated by using the polymer as a chiral stationary phase in HPLC. The polymer was superior to previously reported molecularly imprinted polymers in that unusually high racemic resolution and load capacity were demonstrated.

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  • Biochemistry and Molecular Biology
Original languageEnglish
Pages (from-to)3563-3566
JournalTetrahedron Letters
Volume36
Issue number20
Publication statusPublished - 1995
Publication categoryResearch
Peer-reviewedYes