Recombinant factor VIIa (rFVIIa): its potential role as a hemostatic agent

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Recombinant factor VIIa (rFVIIa): its potential role as a hemostatic agent. / Hedner, Ulla; Brun, Nikolai C.

In: Neuroradiology, Vol. 49, No. 10, 2007, p. 789-793.

Research output: Contribution to journalReview article

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Hedner, Ulla ; Brun, Nikolai C. / Recombinant factor VIIa (rFVIIa): its potential role as a hemostatic agent. In: Neuroradiology. 2007 ; Vol. 49, No. 10. pp. 789-793.

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TY - JOUR

T1 - Recombinant factor VIIa (rFVIIa): its potential role as a hemostatic agent

AU - Hedner, Ulla

AU - Brun, Nikolai C.

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

PY - 2007

Y1 - 2007

N2 - Recombinant activated coagulation factor VII (rFVIIa) was developed for the treatment of patients with hemophilia who have developed inhibitors against the factor they are missing. Hemophilia is a serious bleeding disorder and patients with hemophilia develop repeated spontaneous CNS, joint and muscle bleeding. Any trauma, even mild events, may cause life-threatening bleeding, and without treatment, these patients have a life expectancy of about 16 years. Thus, hemophilia can be regarded as a model of severe bleeding, and an agent capable of inducing hemostasis in severe hemophilia independent of the hemophilia proteins (FVIII or FIX) may also be effective in patients without hemophilia who experience serious bleeds. The availability of rFVIIa stimulated research on the role of FVII and tissue factor (TF) in the hemostatic process. As a result, a picture partly different from the one suggested by previous models [1, 2] has emerged. These previous models basically neglected the role of cells and cell membranes. The importance of platelets and platelet membrane phospholipids in hemostasis has been demonstrated, and the new concept of the hemostatic process, focusing on cell surfaces, has been outlined.

AB - Recombinant activated coagulation factor VII (rFVIIa) was developed for the treatment of patients with hemophilia who have developed inhibitors against the factor they are missing. Hemophilia is a serious bleeding disorder and patients with hemophilia develop repeated spontaneous CNS, joint and muscle bleeding. Any trauma, even mild events, may cause life-threatening bleeding, and without treatment, these patients have a life expectancy of about 16 years. Thus, hemophilia can be regarded as a model of severe bleeding, and an agent capable of inducing hemostasis in severe hemophilia independent of the hemophilia proteins (FVIII or FIX) may also be effective in patients without hemophilia who experience serious bleeds. The availability of rFVIIa stimulated research on the role of FVII and tissue factor (TF) in the hemostatic process. As a result, a picture partly different from the one suggested by previous models [1, 2] has emerged. These previous models basically neglected the role of cells and cell membranes. The importance of platelets and platelet membrane phospholipids in hemostasis has been demonstrated, and the new concept of the hemostatic process, focusing on cell surfaces, has been outlined.

KW - VIIa

KW - tissue factor

KW - intracerebral hemorrhage

KW - recombinant coagulation factor

KW - hemostasis

U2 - 10.1007/s00234-007-0240-2

DO - 10.1007/s00234-007-0240-2

M3 - Review article

VL - 49

SP - 789

EP - 793

JO - Neuroradiology

JF - Neuroradiology

SN - 1432-1920

IS - 10

ER -