Recommendations for premature ovarian insufficiency surveillance for female survivors of childhood, adolescent, and young adult cancer: A report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup consortium

Research output: Contribution to journalReview article


Purpose: Female survivors of childhood, adolescent, and young adult (CAYA) cancer who were treated with alkylating agents and/or radiation, with potential exposure of the ovaries, have an increased risk of premature ovarian insufficiency (POI). Clinical practice guidelines can facilitate these survivors' access to optimal treatment of late effects that may improve health and quality of survival; however, surveillance recommendations vary among the existing long-term follow-up guidelines, which impedes the implementation of screening. Patients and Methods: The present guideline was developed by using an evidence-based approach and summarizes harmonized POI surveillance recommendations for female survivors of CAYA cancer who were diagnosed at age < 25 years. The recommendations were formulated by an international multidisciplinary panel and graded according to the strength of the evidence and the potential benefit gained from early detection and intervention. The harmonized POI surveillance recommendations were developed by using a transparent process and are intended to facilitate care for survivors of CAYA cancer. Results and Conclusion: The harmonized set of POI surveillance recommendations is intended to be scientifically rigorous, to positively influence health outcomes, and to facilitate the care for female survivors of CAYA cancer.


  • Wendy Van Dorp
  • Renée L. Mulder
  • Leontien C M Kremer
  • Melissa M. Hudson
  • Marry M. Van Den Heuvel-Eibrink
  • Marleen H. Van Den Berg
  • Jennifer M. Levine
  • Eline Van Dulmen-Den Broeder
  • Natascia Di Iorgi
  • Assunta Albanese
  • Saro H. Armenian
  • Smita Bhatia
  • Louis S. Constine
  • Andreas Corrias
  • Rebecca Deans
  • Uta Dirksen
  • Clarisa R. Gracia
  • Leah Kroon
  • Cornelis B. Lambalk
  • Wendy Landier
  • Gill Levitt
  • Alison Leiper
  • Lillian Meacham
  • Alesandro Mussa
  • Sebastian J. Neggers
  • Kevin C. Oeffinger
  • Alberto Revelli
  • Hanneke M. Van Santen
  • Roderick Skinner
  • Andrew Toogood
  • William H. Wallace
  • Riccardo Haupt
External organisations
  • Academic Medical Center
  • University of New South Wales
  • Universitätsklinikum Münster
  • Memorial Sloan-Kettering Cancer Center
  • New Queen Elizabeth Hospital
  • University of Edinburgh
  • Erasmus University Rotterdam
  • Emma Children’s Hospital
  • VU University Medical Center
  • Princess Maxima Center for Pediatric Oncology/Hematology
  • Wilhelmina Children’s Hospital
  • St Jude Children´s Research Hospital, Memphis
  • Columbia University
  • University of Rochester
  • University of Genoa
  • University of Turin
  • Gaslini Children's Hospital
  • St George's Hospital, London
  • Great Ormond Street Hospital for Children NHS Foundation Trust
  • University of Newcastle upon Tyne
  • Royal Hospital for Sick Children, Edinburgh
  • City of Hope National Medical Center
  • University of Alabama
  • University of Münster
  • University of Pennsylvania
  • Seattle Children’s Hospital
  • Emory University
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
  • Pediatrics
Original languageEnglish
Pages (from-to)3440-3450
Number of pages11
JournalJournal of Clinical Oncology
Issue number28
Publication statusPublished - 2016 Oct 1
Publication categoryResearch