Reduced aortic wall stress in diabetes mellitus
Research output: Contribution to journal › Article
Objective. Most risk factors are similar for abdominal aortic aneurysm (AAA) and atherosclerosis, e.g. smoking, male gender, age, high blood pressure, hyperlipidemia. Diabetes mellitus however, is a risk factor for atherosclerosis, but diabetic patients seldom develop AAA. The reason for this discrepancy is unknown. Increased aortic wall stress seems to be all etiologic factor in the formation, growth and rupture of AAA in man. The aim of our study was to study the wall stress in the abdominal aorta in diabetic patients compared with healthy controls. Methods. 39 patients with diabetes mellitus and 46 age - and sex matched healthy subjects were examined with B-mode ultrasound to determine the lumen diameter (LD) and intima-media thickness (IMT) in the abdominal aorta (AA) and the common carotid artery (CCA). Diastolic blood pressure (DBP) was measured non-invasively in the brachial artery. LaPlace law was used to calculate circumferential wall stress. Results. Age, DBP, and LD in the abdominal aorta were not significantly different in the diabetic patients compared to controls. IMT in the AA was larger in the diabetic patients, 0.89 +/- 0.17 vs 0.73 +/- 0.11 mm (p <.001). Accordingly aortic wall stress was reduced in the diabetics, 7.8 +/- 1.7 x 10(5) vs 9.7 +/- 1.9 x 10(5) dynes/cm(2) (P <.001). Conclusions. Wall stress in the abdominal aorta is reduced in diabetes mellitus. This is mainly due to a thicker aortic wall compared to healthy controls. The reduced aortic wall stress coincides with the fact that epidemiological studies have shown a decreased risk of aneurysm development in diabetic patients.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||European Journal of Vascular and Endovascular Surgery|
|Publication status||Published - 2007|
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Physiology and Nuclear Medicine Unit (013242320), Diabetes Epidemiology and Neuropathy (013241560)