Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs

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Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs. / Thorngren-Jerneck, Kristina; Ley, David; Hellström-Westas, Lena; Hernandez-Andrade, Edgar; Lingman, Göran; Ohlsson, Tomas G; Oskarsson, Gylfi; Pesonen, Erkki; Sandell, Anders; Strand, Sven-Erik; Werner, Olof; Marsal, Karel.

In: Journal of Neuroscience Research, Vol. 66, No. 5, 2001, p. 844-850.

Research output: Contribution to journalArticle

Harvard

Thorngren-Jerneck, K, Ley, D, Hellström-Westas, L, Hernandez-Andrade, E, Lingman, G, Ohlsson, TG, Oskarsson, G, Pesonen, E, Sandell, A, Strand, S-E, Werner, O & Marsal, K 2001, 'Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs', Journal of Neuroscience Research, vol. 66, no. 5, pp. 844-850. https://doi.org/10.1002/jnr.10051

APA

CBE

Thorngren-Jerneck K, Ley D, Hellström-Westas L, Hernandez-Andrade E, Lingman G, Ohlsson TG, Oskarsson G, Pesonen E, Sandell A, Strand S-E, Werner O, Marsal K. 2001. Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs. Journal of Neuroscience Research. 66(5):844-850. https://doi.org/10.1002/jnr.10051

MLA

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Author

Thorngren-Jerneck, Kristina ; Ley, David ; Hellström-Westas, Lena ; Hernandez-Andrade, Edgar ; Lingman, Göran ; Ohlsson, Tomas G ; Oskarsson, Gylfi ; Pesonen, Erkki ; Sandell, Anders ; Strand, Sven-Erik ; Werner, Olof ; Marsal, Karel. / Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs. In: Journal of Neuroscience Research. 2001 ; Vol. 66, No. 5. pp. 844-850.

RIS

TY - JOUR

T1 - Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs

AU - Thorngren-Jerneck, Kristina

AU - Ley, David

AU - Hellström-Westas, Lena

AU - Hernandez-Andrade, Edgar

AU - Lingman, Göran

AU - Ohlsson, Tomas G

AU - Oskarsson, Gylfi

AU - Pesonen, Erkki

AU - Sandell, Anders

AU - Strand, Sven-Erik

AU - Werner, Olof

AU - Marsal, Karel

PY - 2001

Y1 - 2001

N2 - The effects of fetal asphyxia on cerebral function and development, involve the transition from fetal to neonatal life. Changes in cerebral glucose metabolism may be an early postnatal indicator of fetal asphyxia. The objective is to develop an experimental lamb model involving the transition from fetal to neonatal life and to examine the effect of fetal asphyxia with cerebral hypoxic ischemia on early postnatal cerebral glucose metabolism. Fetal asphyxia was induced by total umbilical cord occlusion in eight near-term fetal lambs (134-138 days) with the ewe under isoflurane-opiate anesthesia. The mean occlusion time until cardiac arrest was 14.5 (4.2) min (SD). Lambs were immediately delivered and standardized resuscitation was instituted after 2 min asystole. At 4 hr postnatal age, [18-F]Fluoro-2-deoxy-glucose (18-FDG) was injected intravenously in eight asphyxiated lambs and in eight controls. Cerebral glucose metabolism was examined by positron emission tomography (PET). As a result the mean arterial blood pressure, acid-base values, blood glucose and serum lactate at 4 hr postnatal age did not differ significantly between lambs subjected to umbilical cord occlusion and controls. EEG was abnormal in all lambs subjected to cord occlusion and normal in the controls at 4 hr postnatal age. Global cerebral metabolic rate (CMRgl) as determined by PET was significantly lower in lambs subjected to cord occlusion mean/median (SD) 22.2/19.6 (8.4) micromol/min/100 g) than in controls mean/median (SD) 37.8/35.9 (6.1); P < 0.01). Global CMRgl is significantly reduced in newborn lambs 4 hr after fetal asphyxia induced by umbilical cord occlusion. A reduction in CMRgl is an early indicator of global hypoxic cerebral ischemia.

AB - The effects of fetal asphyxia on cerebral function and development, involve the transition from fetal to neonatal life. Changes in cerebral glucose metabolism may be an early postnatal indicator of fetal asphyxia. The objective is to develop an experimental lamb model involving the transition from fetal to neonatal life and to examine the effect of fetal asphyxia with cerebral hypoxic ischemia on early postnatal cerebral glucose metabolism. Fetal asphyxia was induced by total umbilical cord occlusion in eight near-term fetal lambs (134-138 days) with the ewe under isoflurane-opiate anesthesia. The mean occlusion time until cardiac arrest was 14.5 (4.2) min (SD). Lambs were immediately delivered and standardized resuscitation was instituted after 2 min asystole. At 4 hr postnatal age, [18-F]Fluoro-2-deoxy-glucose (18-FDG) was injected intravenously in eight asphyxiated lambs and in eight controls. Cerebral glucose metabolism was examined by positron emission tomography (PET). As a result the mean arterial blood pressure, acid-base values, blood glucose and serum lactate at 4 hr postnatal age did not differ significantly between lambs subjected to umbilical cord occlusion and controls. EEG was abnormal in all lambs subjected to cord occlusion and normal in the controls at 4 hr postnatal age. Global cerebral metabolic rate (CMRgl) as determined by PET was significantly lower in lambs subjected to cord occlusion mean/median (SD) 22.2/19.6 (8.4) micromol/min/100 g) than in controls mean/median (SD) 37.8/35.9 (6.1); P < 0.01). Global CMRgl is significantly reduced in newborn lambs 4 hr after fetal asphyxia induced by umbilical cord occlusion. A reduction in CMRgl is an early indicator of global hypoxic cerebral ischemia.

KW - fetal lamb

KW - asphyxia

KW - cerebral glucose metabolism

KW - positron emission tomography

U2 - 10.1002/jnr.10051

DO - 10.1002/jnr.10051

M3 - Article

VL - 66

SP - 844

EP - 850

JO - Journal of Neuroscience Research

T2 - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 1097-4547

IS - 5

ER -