Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines

Research output: Contribution to journalArticle

Abstract

The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry

Keywords

  • amines, copper, enamines, enantioselectivity, hydroamination
Original languageEnglish
Pages (from-to)8551-8555
JournalAngewandte Chemie - International Edition
Volume58
Issue number25
Early online date2019
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes

Related research output

Lu Yu, 2019 Aug 27, Lund: Printed in Sweden by Media-Tryck, Lund University. 142 p.

Research output: ThesisDoctoral Thesis (compilation)

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