Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects

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Bibtex

@article{6e2fd6746f2344f896ae41b69d2aa4aa,
title = "Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects",
abstract = "Background: The APOE epsilon 4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon 4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE epsilon 4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. Methods: Data from 16 centers across Europe were analyzed. Results: A north-south gradient in APOE epsilon 4 prevalence existed in the total sample (62.7{\%} for APOE epsilon 4 carriers in the northern region, 42.1{\%} in the middle region, and 31.5{\%} in the southern region) and in subjects with SCI and amnestic MCI separately. Only in Middle Europe was the APOE epsilon 4 allele significantly associated with poor performance on tests of delayed recall and learning, as well as with the amnestic subtype of MCI. Conclusion: The APOE epsilon 4 allele frequencies in subjects with SCI and amnestic MCI have a north-south gradient. The relation between the APOE epsilon 4 allele and cognition is region dependent. Copyright (C) 2011 S. Karger AG, Basel",
keywords = "Alzheimer's disease, APOE epsilon 4 allele, Europe, Gradient",
author = "J. Norberg and C. Graff and O. Almkvist and M. Ewers and Frisoni, {G. B.} and L. Froelich and H. Hampel and Jones, {R. W.} and Kehoe, {P. G.} and H. Lenoir and Lennart Minthon and F. Nobili and Rikkert, {M. Olde} and Rigaud, {A. -S.} and P. Scheltens and H. Soininen and L. Spiru and M. Tsolaki and Wahlund, {L. -O.} and B. Vellas and G. Wilcock and Elias-Sonnenschein, {L. S.} and Verhey, {F. R. J.} and Visser, {P. J.}",
year = "2011",
doi = "10.1159/000330492",
language = "English",
volume = "32",
pages = "135--142",
journal = "Dementia and Geriatric Cognitive Disorders",
issn = "1420-8008",
publisher = "Karger",
number = "2",

}