Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects

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Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects. / Norberg, J.; Graff, C.; Almkvist, O.; Ewers, M.; Frisoni, G. B.; Froelich, L.; Hampel, H.; Jones, R. W.; Kehoe, P. G.; Lenoir, H.; Minthon, Lennart; Nobili, F.; Rikkert, M. Olde; Rigaud, A. -S.; Scheltens, P.; Soininen, H.; Spiru, L.; Tsolaki, M.; Wahlund, L. -O.; Vellas, B.; Wilcock, G.; Elias-Sonnenschein, L. S.; Verhey, F. R. J.; Visser, P. J.

In: Dementia and Geriatric Cognitive Disorders, Vol. 32, No. 2, 2011, p. 135-142.

Research output: Contribution to journalArticle

Harvard

Norberg, J, Graff, C, Almkvist, O, Ewers, M, Frisoni, GB, Froelich, L, Hampel, H, Jones, RW, Kehoe, PG, Lenoir, H, Minthon, L, Nobili, F, Rikkert, MO, Rigaud, A-S, Scheltens, P, Soininen, H, Spiru, L, Tsolaki, M, Wahlund, L-O, Vellas, B, Wilcock, G, Elias-Sonnenschein, LS, Verhey, FRJ & Visser, PJ 2011, 'Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects', Dementia and Geriatric Cognitive Disorders, vol. 32, no. 2, pp. 135-142. https://doi.org/10.1159/000330492

APA

Norberg, J., Graff, C., Almkvist, O., Ewers, M., Frisoni, G. B., Froelich, L., ... Visser, P. J. (2011). Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects. Dementia and Geriatric Cognitive Disorders, 32(2), 135-142. https://doi.org/10.1159/000330492

CBE

Norberg J, Graff C, Almkvist O, Ewers M, Frisoni GB, Froelich L, Hampel H, Jones RW, Kehoe PG, Lenoir H, Minthon L, Nobili F, Rikkert MO, Rigaud A-S, Scheltens P, Soininen H, Spiru L, Tsolaki M, Wahlund L-O, Vellas B, Wilcock G, Elias-Sonnenschein LS, Verhey FRJ, Visser PJ. 2011. Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects. Dementia and Geriatric Cognitive Disorders. 32(2):135-142. https://doi.org/10.1159/000330492

MLA

Vancouver

Author

Norberg, J. ; Graff, C. ; Almkvist, O. ; Ewers, M. ; Frisoni, G. B. ; Froelich, L. ; Hampel, H. ; Jones, R. W. ; Kehoe, P. G. ; Lenoir, H. ; Minthon, Lennart ; Nobili, F. ; Rikkert, M. Olde ; Rigaud, A. -S. ; Scheltens, P. ; Soininen, H. ; Spiru, L. ; Tsolaki, M. ; Wahlund, L. -O. ; Vellas, B. ; Wilcock, G. ; Elias-Sonnenschein, L. S. ; Verhey, F. R. J. ; Visser, P. J. / Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects. In: Dementia and Geriatric Cognitive Disorders. 2011 ; Vol. 32, No. 2. pp. 135-142.

RIS

TY - JOUR

T1 - Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects

AU - Norberg, J.

AU - Graff, C.

AU - Almkvist, O.

AU - Ewers, M.

AU - Frisoni, G. B.

AU - Froelich, L.

AU - Hampel, H.

AU - Jones, R. W.

AU - Kehoe, P. G.

AU - Lenoir, H.

AU - Minthon, Lennart

AU - Nobili, F.

AU - Rikkert, M. Olde

AU - Rigaud, A. -S.

AU - Scheltens, P.

AU - Soininen, H.

AU - Spiru, L.

AU - Tsolaki, M.

AU - Wahlund, L. -O.

AU - Vellas, B.

AU - Wilcock, G.

AU - Elias-Sonnenschein, L. S.

AU - Verhey, F. R. J.

AU - Visser, P. J.

PY - 2011

Y1 - 2011

N2 - Background: The APOE epsilon 4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon 4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE epsilon 4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. Methods: Data from 16 centers across Europe were analyzed. Results: A north-south gradient in APOE epsilon 4 prevalence existed in the total sample (62.7% for APOE epsilon 4 carriers in the northern region, 42.1% in the middle region, and 31.5% in the southern region) and in subjects with SCI and amnestic MCI separately. Only in Middle Europe was the APOE epsilon 4 allele significantly associated with poor performance on tests of delayed recall and learning, as well as with the amnestic subtype of MCI. Conclusion: The APOE epsilon 4 allele frequencies in subjects with SCI and amnestic MCI have a north-south gradient. The relation between the APOE epsilon 4 allele and cognition is region dependent. Copyright (C) 2011 S. Karger AG, Basel

AB - Background: The APOE epsilon 4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon 4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE epsilon 4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. Methods: Data from 16 centers across Europe were analyzed. Results: A north-south gradient in APOE epsilon 4 prevalence existed in the total sample (62.7% for APOE epsilon 4 carriers in the northern region, 42.1% in the middle region, and 31.5% in the southern region) and in subjects with SCI and amnestic MCI separately. Only in Middle Europe was the APOE epsilon 4 allele significantly associated with poor performance on tests of delayed recall and learning, as well as with the amnestic subtype of MCI. Conclusion: The APOE epsilon 4 allele frequencies in subjects with SCI and amnestic MCI have a north-south gradient. The relation between the APOE epsilon 4 allele and cognition is region dependent. Copyright (C) 2011 S. Karger AG, Basel

KW - Alzheimer's disease

KW - APOE epsilon 4 allele

KW - Europe

KW - Gradient

U2 - 10.1159/000330492

DO - 10.1159/000330492

M3 - Article

VL - 32

SP - 135

EP - 142

JO - Dementia and Geriatric Cognitive Disorders

T2 - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - 2

ER -