Relevance of biomarkers across different neurodegenerative

Research output: Contribution to journalReview article

Abstract

Background: The panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and increasing use, appropriate implementation and interpretation are paramount. Various biomarkers feature nuanced differences in strengths, limitations, and biases that must be considered when investigating disease etiology and clinical utility. For example, neuropathological investigations of Alzheimer's disease pathogenesis can fall in disagreement with conclusions reached by biomarker-based investigations. Considering the varied strengths, limitations, and biases of different research methodologies and approaches may help harmonize disciplines within the neurodegenerative disease field. Purpose of review: Along with separate review articles covering fluid and imaging biomarkers in this issue of Alzheimer's Research and Therapy, we present the result of a discussion from the 2019 Biomarkers in Neurodegenerative Diseases course at the University College London. Here, we discuss themes of biomarker use in neurodegenerative disease research, commenting on appropriate use, interpretation, and considerations for implementation across different neurodegenerative diseases. We also draw attention to areas where biomarker use can be combined with other disciplines to understand issues of pathophysiology and etiology underlying dementia. Lastly, we highlight novel modalities that have been proposed in the landscape of neurodegenerative disease research and care.

Details

Authors
  • Alexander J. Ehrenberg
  • Ayesha Khatun
  • Emma Coomans
  • Matthew J. Betts
  • Federica Capraro
  • Elisabeth H. Thijssen
  • Konstantin Senkevich
  • Tehmina Bharucha
  • Mehrsa Jafarpour
  • Peter N.E. Young
  • William Jagust
  • Stephen F. Carter
  • Tammaryn Lashley
  • Lea T. Grinberg
  • Nicholas J. Ashton
  • Jörg Hanrieder
  • Henrik Zetterberg
  • Ross W. Paterson
Organisations
External organisations
  • University of California, San Francisco
  • University of California, Berkeley
  • Amsterdam UMC - Vrije Universiteit Amsterdam
  • German Center for Neurodegenerative Diseases (DZNE), Bonn
  • Otto von Guericke University Magdeburg
  • Francis Crick Institute
  • Petersburg Nuclear Physics Institute (PNPI)
  • Pavlov University
  • University of Oxford
  • University College London
  • Sahlgrenska Academy
  • Lund University
  • Lawrence Berkeley National Laboratory
  • University of Cambridge
  • University of Manchester
  • University of São Paulo
  • Karolinska Institutet
  • King's College London
  • Sahlgrenska University Hospital
  • NIHR Maudsley Biomedical Research Centre
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Alzheimer's disease, Amyloid, Biomarkers, Cerebrospinal fluid, Magnetic resonance imaging, Neurodegenerative diseases, Neurofilament light chain, Plasma biomarkers, Positron emission tomography, Tau
Original languageEnglish
Article number56
JournalAlzheimer's Research and Therapy
Volume12
Publication statusPublished - 2020 May 13
Publication categoryResearch
Peer-reviewedYes