Renal and cardiorespiratory effects of treatment with lactated Ringer's solution or physiologic saline (0.9% NaCl) solution in cats with experimentally induced urethral obstruction

Research output: Contribution to journalArticle


OBJECTIVE: To compare the renal and cardiorespiratory effects of IV treatment with lactated Ringer's solution (LRS) or physiologic saline (0.9% NaCl) solution (PSS) in severely decompensated cats with urethral obstruction (UO).

ANIMALS: 14 cats (4 cats were used only to establish infusion rates).

PROCEDURES: An occluded urethral catheter was used to induce UO in each cat. After development of severe metabolic acidosis, hyperkalemia, and postrenal azotemia, the obstruction was relieved (0 hours); LRS or PSS (5 cats/group) was administered IV (gradually decreasing rate) beginning 15 minutes before and continuing for 48 hours after UO relief. Ten minutes before urethral catheter placement (baseline), at start of fluid therapy (SFT), and at intervals during fluid administration, various physical and clinicopathologic evaluations were performed.

RESULTS: Metabolic acidosis was detected in the PSS-treated group at SFT and 2 hours after relief of UO and in the LRS-treated group only at SFT The PSS-treated group had significantly lower blood pH and bicarbonate concentrations at 8 through 48 hours and lower base excess values at 2 through 48 hours, compared with the LRS-treated group. Hypocalcemia and hypernatremia were detected in the PSS-treated group at 2 and 12 hours, respectively. Absolute serum potassium and chloride concentrations did not differ significantly between groups at any time point.

CONCLUSIONS AND CLINICAL RELEVANCE: Treatment with LRS or PSS appeared to be safe and effective in cats with experimentally induced UO; however, LRS was more efficient in restoring the acid-base and electrolyte balance in severely decompensated cats with UO.


  • Marina G M C M Cunha
  • Gabrielle C Freitas
  • Adriano B Carregaro
  • Kleber Gomes
  • Joäo P M C M Cunha
  • Diego V Beckmann
  • Ney L Pippi
External organisations
  • Federal University of Santa Maria
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Veterinary Science
  • Pharmaceutical Sciences


  • Animals, Body Temperature/drug effects, Cat Diseases/drug therapy, Cats, Diuresis/drug effects, Fluid Therapy/methods, Heart Rate/drug effects, Isotonic Solutions/therapeutic use, Kidney/drug effects, Male, Orchiectomy, Ringer's Lactate, Serum Albumin/drug effects, Sodium Chloride/therapeutic use, Urethral Obstruction/drug therapy
Original languageEnglish
Pages (from-to)840-6
Number of pages7
JournalAmerican Journal of Veterinary Research
Issue number7
Publication statusPublished - 2010 Jul
Publication categoryResearch
Externally publishedYes