Renal cell carcinoma recurrences and metastases in primary non-metastatic patients: a population-based study.

Research output: Contribution to journalArticle

Abstract

To present the occurrence of metastases and local recurrences in primary non-metastatic patients with renal cell carcinoma (RCC) in a contemporary Swedish population-based cohort. Between 2005 and 2009, a total of 4527 patients were included in the prospective National Swedish Kidney Cancer Register accounting for nearly all RCC patients in Sweden. Among M0 patients, 472 (13 %) had no follow-up data registered within 5-year follow-up time and were excluded from the analysis.
In total, 939 (21 %) had distant metastases at presentation with a decrease from 23 to 18 % during the inclusion period. Of 3107 patients with follow-up data and with M0 disease, 623 (20 %) were diagnosed with a tumor recurrence during 5-year follow-up. Mean time to recurrence was 24 months (SD ± 20 months). Among these, 570 patients (92 %) were at primary diagnosis treated with radical nephrectomy, 23 patients (3.7 %) with partial nephrectomy and 12 patients (1.9 %) with minimally invasive treatments. The most frequent sites of metastases were lung (54 %), lymph nodes (22 %) and bone (20 %). The treatment of recurrence was in 50 % systemic treatments, while metastasectomy was performed in 17 % of the patients, out of which 68 % were with a curative intention.
In this population-based study, 21 % of the patients had metastatic disease at presentation, with a decreasing trend over the study period. During 5-year follow-up, 20 % of the primary non-metastatic patients had recurrent disease. Of the patients with recurrence, half were given systemic oncological treatment and 17 % underwent metastasectomy.

Details

Authors
  • Saeed Dabestani
  • Andreas Thorstenson
  • Per Lindblad
  • Ulrika Harmenberg
  • Börje Ljungberg
  • Sven Lundstam
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
  • Urology and Nephrology
Original languageEnglish
JournalWorld Journal of Urology
Early online date2016 Feb 5
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes

Related research output

Saeed Dabestani, 2018, Lund: Lund University: Faculty of Medicine. 90 p.

Research output: ThesisDoctoral Thesis (compilation)

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