Repairing the brain: Gene therapy

Research output: Contribution to journalReview article

Abstract

In vivo gene therapy for neurodegenerative disorders has turned out to be a formidable challenge. It is a field not much older than twenty years, but we were many who would have predicted a much easier path towards the clinic using this treatment modality. For Parkinson's disease patients, this has meant a frustrating wait, seeing many promising therapies being forgotten after a few pre-clinical proof-of-concept studies. The reasons for this are both scientific and economical. However, this is slowly but surely changing and over the next two decades we will see a very exciting development in this field. In a foreseeable future, gene therapy will be a very natural component of many clinical therapies, not least in Parkinson's disease.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Clinical trial, Dependovirus, Gene editing, Genetic therapy, Neuroprotection, Parkinson's disease, Rejuvenation
Original languageEnglish
Pages (from-to)S123-S130
JournalJournal of Parkinson's Disease
Volume8
Issue numbers1
Publication statusPublished - 2018
Publication categoryResearch
Peer-reviewedYes