Reproductive Factors and Breast Cancer - Parity, Breastfeeding and Genetic Predisposition in Relation to Risk and Prognosis

Research output: ThesisDoctoral Thesis (compilation)

Abstract

The aim of this thesis was to study reproductive factors and genetic polymorphisms in relation to breast
cancer risk and survival. An important component of this was to investigate the risk of specific breast cancer
subgroups.
The association between parity and breast cancer-specific survival was studied among 4,453 women diagnosed
with breast cancer in Malmö, Sweden.
It was found that:
• Nulliparity and multiparity (≥4 children) were associated with a worse survival after breast cancer than
that of women with one child.
Parity, age at first childbirth and breastfeeding were examined in relation to the risk of specific breast
cancer subgroups among 17,035 women in The Malmö Diet and Cancer Study.
It was found that:
• Nulliparous women had a higher risk of more aggressive breast cancer subgroups than women with one
child.
• Women with a late first childbirth (>30 years) had a higher risk of more aggressive breast cancer subgroups
than women with an early first childbirth (≤20 years).
• Long duration of breastfeeding was associated with relatively aggressive breast cancer subgroups.
The potential interaction between parity/age at first childbirth and single nucleotide polymorphisms
(SNPs) was studied in The Malmö Diet and Cancer Study.
It was found that:
• Seven out of 14 investigated SNPs showed a statistically significant association with breast cancer risk.
Certain combinations of parity/age at first childbirth and SNPs might alter the susceptibility to breast
cancer.
We conclude that parity, breastfeeding and genetic predispostion are related to breast cancer risk and/or
prognosis.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Surgery
  • Clinical Medicine

Keywords

  • subgroups, stage, survival, Breast cancer risk, parity, nulliparity, multiparity, breastfeeding, age at first birth, single nucleotide polymophisms
Original languageEnglish
QualificationDoctor
Awarding Institution
Supervisors/Assistant supervisor
Award date2011 Feb 11
Print ISBNs978-91-86671-59-4
Publication statusPublished - 2011
Publication categoryResearch

Bibliographic note

Defence details Date: 2011-02-11 Time: 09:00 Place: Kvinnoklinikens aula, Ing 74, plan 3, SUS Malmö External reviewer(s) Name: Ekbom, Anders Title: Prof Affiliation: Institutionen för Medicin, Solna (MedS), Karolinska Universitetssjukhuset, 171 76 Stockholm ---

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