Resistance to phagocytosis in Streptococcus pyogenes
Research output: Thesis › Doctoral Thesis (compilation)
Phagocytosis of Streptococcus pyogenes is complement dependent. However, the cell wall-associated M protein, which exists in >100 different serotypes (M types), enables the bacteria to evade phagocytosis. To analyze the mechanisms by which M protein confers this ability we used, as model systems, two representative M proteins, the M22 and M5 proteins, which have properties typical for many M proteins of different M type.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Award date||2005 May 21|
|Publication status||Published - 2005|
Defence details Date: 2005-05-21 Time: 09:30 Place: Segerfalkssalen External reviewer(s) Name: Wessels, Michael R. Title: professor Affiliation: Harvad Medical School ---
F Carlsson, K Berggård, M Stålhammar-Carlemalm and G Lindahl. 2003. Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein. J Exp Med, vol 198 pp 1057-1068.
F Carlsson, C Sandin and G Lindahl. 2005. Human fibrinogen bound to Streptococcus pyogenes M protein inhibits complement deposition via the classical pathway. Mol Microbiol., vol 56 pp 28-39.