Resistens mot acetylsalicylsyra - klinisk diagnos utan klarlagd mekanism

Research output: Contribution to journalArticle

Abstract

A review on the subject of aspirin resistance and its role in vascular diseases is presented. Although the clinical diagnosis of aspirin resistance is frequently made, little is known about its biochemical background. Only a few follow-up studies, with varying design, have dealt with the possible association between an aspirin resistant phenotype and clinical outcome in patients with atherothrombosis. However, it was recently shown that ibuprofen acts as a competitive inhibitor in the blockage of COX-1. This pharmacodynamic interaction results in secondary aspirin resistance, which may have clinical significance in patients taking both medicines. With the complex nature of vascular diseases in mind, it is not surprising that aspirin used as a single preventive strategy fails in many cases. At present, there is no clear evidence that treatment failure is associated with a particular aspirin resistant phenotype.

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Subject classification (UKÄ) – MANDATORY

  • Medicinal Chemistry

Keywords

  • Platelet Aggregation Inhibitors: metabolism, Platelet Aggregation: drug effects, Ibuprofen: metabolism, Ibuprofen: pharmacology, Humans, Phenotype, Fibrinolytic Agents: pharmacology, Fibrinolytic Agents: metabolism, English Abstract, Drug Tolerance: genetics, Drug Resistance: genetics, Drug Interactions, Cyclooxygenase Inhibitors: pharmacology, Cyclooxygenase Inhibitors: metabolism, Cardiovascular Diseases: metabolism, Cardiovascular Diseases: drug therapy, Bleeding Time, Aspirin: metabolism, Aspirin: pharmacology, Platelet Aggregation Inhibitors: pharmacology
Translated title of the contributionAcetylsalicylic acid resistance--clinical diagnosis with unclear mechanism
Original languageSwedish
Pages (from-to)3504-3509
JournalLäkartidningen
Volume101
Issue number45
Publication statusPublished - 2004
Publication categoryResearch
Peer-reviewedYes