Respiratory mechanics in patients ventilated for critical lung disease

Research output: Contribution to journalArticle


title = "Respiratory mechanics in patients ventilated for critical lung disease",
abstract = "Respiratory mechanics, using flow interruption, was previously studied during the complete breath in healthy ventilated man, numerical techniques relieving constraints regarding flow pattern. The classical linear model of non-Newtonian behaviour was found to be valid. The present study was extended to subjects with critical lung disease. Subjects with acute lung injury (ALI; n = 2), acute respiratory distress syndrome (ARDS; n = 4), and chronic obstructive pulmonary disease (COPD; n = 3) were studied with and without positive end-expiratory pressure (PEEP). Functional residual capacity (FRC) was measured with sulphur hexafluoride (SF6) wash-out. The static pressure-volume (P-V) curve was linear at zero end-expiratory pressure (ZEEP), but nonlinear at PEEP. Its hysteresis was nonsignificant. In ALI/ARDS, PEEP increased lung volume by distension and recruitment, but only by distension in COPD. In ALI/ARDS, resistance was increased, at ZEEP. In COPD, resistance became extremely high during expiration at ZEEP. In ALI/ARDS at ZEEP, non-Newtonian behaviour, representing tissue stress relaxation and pendel-luft, complied with the classical linear model. At PEEP, the non-Newtonian compliance became volume-dependent to an extent correlated to the nonlinearity of the static P-V curve. In COPD, non-Newtonian behaviour was adequately explained only with a model with different inspiratory and expiratory behaviour. The classical model of the respiratory system is valid in ALI/ARDS at ZEEP. More advanced models are needed at PEEP and in COPD.",
keywords = "Adult, Aged, Aged, 80 and over, Female, Functional Residual Capacity, Humans, Infant, Newborn, Lung, Lung Diseases, Obstructive, Male, Middle Aged, Positive-Pressure Respiration, Respiration, Artificial, Respiratory Distress Syndrome, Adult, Respiratory Distress Syndrome, Newborn, Respiratory Mechanics, Respiratory Physiological Phenomena, Journal Article, Research Support, Non-U.S. Gov't",
author = "L Beydon and C Svantesson and K Brauer and Francois Lemaire and B Jonson",
year = "1996",
month = "2",
language = "English",
volume = "9",
pages = "262--73",
journal = "European Respiratory Journal",
issn = "1399-3003",
publisher = "Eur Respiratory Soc",
number = "2",