Reversible Conformational Transitions of a Polymer Brush Containing Boronic Acid and its Interaction with Mucin Glycoprotein.

Research output: Contribution to journalArticle

Abstract

Reversible changes of the height of a polymer brush containing phenylboronic acid were studied. The polymer brush thickness underwent reversible changes of 0.5-1 nm, in response to the changes in composition of the contacting aqueous phase from deionized water to bicarbonate buffer and vice versa, apparently due to the conformational transition of the weak polyelectrolyte to the more extended electrically charged state. Adsorption of mucin glycoprotein to the polymer brush took place due to boronate/sugar interactions between the glycoprotein and the graft copolymer and resulted in further increase of the brush height by ca. 1.5 nm, as observed by means of spectral correlation spectroscopy and ellipsometry.

Details

Authors
  • Alexander E Ivanov
  • Nadezda Solodukhina
  • Marie Wahlgren
  • Lars Nilsson
  • Alexander A Vikhrov
  • Maxim P Nikitin
  • Alexey V Orlov
  • Petr I Nikitin
  • Marina Kuzimenkova
  • Vitali P Zubov
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Bio Materials
Original languageEnglish
Pages (from-to)275-284
JournalMacromolecular Bioscience
Volume11
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes