Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases

Research output: Contribution to journalArticle

Abstract

PURPOSE OF REVIEW: Matrix metalloproteinases (MMPs) are a family of over 20 zinc-dependent proteases with different biological and pathological activities, and many have been implicated in several diseases. Although nonselective MMP inhibitors are known to induce serious side-effects, targeting individual MMPs may offer a safer therapeutic potential for several diseases. Hence, we provide a concise overview on MMP-12, given its association with pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and other progressive pulmonary fibrosis (PPF), which may also occur in coronavirus disease 2019. RECENT FINDINGS: In asthma, COPD, and PPF, increased MMP-12 levels have been associated with inflammation and/or structural changes within the lungs and negatively correlated with functional parameters. Increased pulmonary MMP-12 levels and MMP-12 gene expression have been related to disease severity in asthma and COPD. Targeting MMP-12 showed potential in animal models of pulmonary diseases but human data are still very scarce. SUMMARY: Although there may be a potential role of MMP-12 in asthma, COPD and PPF, several pathophysiological aspects await elucidation. Targeting MMP-12 may provide further insights into MMP-12 related mechanisms and how this translates into clinical outcomes; this warrants further research.

Details

Authors
  • Khalid Abd-Elaziz
  • Milos Jesenak
  • Martina Vasakova
  • Zuzana Diamant
Organisations
External organisations
  • University Hospital Martin
  • Charles University in Prague
  • University Medical Center Groningen
  • Skåne University Hospital
  • Thomayer Hospital
  • Catholic University of Leuven
  • University of Groningen
  • Comenius University
  • QPS-Netherlands
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Respiratory Medicine and Allergy
Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalCurrent Opinion in Pulmonary Medicine
Volume27
Issue number1
Publication statusPublished - 2021
Publication categoryResearch
Peer-reviewedYes