Rho-guanine nucleotide exchange factors during development: Force is nothing without control.

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Rho-guanine nucleotide exchange factors during development: Force is nothing without control. / Mulinari, Shai; Häcker, Udo.

In: Small GTPases, Vol. 1, No. 1, 2010, p. 28-43.

Research output: Contribution to journalArticle

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TY - JOUR

T1 - Rho-guanine nucleotide exchange factors during development: Force is nothing without control.

AU - Mulinari, Shai

AU - Häcker, Udo

PY - 2010

Y1 - 2010

N2 - The development of multicellular organisms is associated with extensive rearrangements of tissues and cell sheets. The driving force for these rearrangements is generated mostly by the actin cytoskeleton. In order to permit the reproducible development of a specific body plan, dynamic reorganization of the actin cytoskeleton must be precisely coordinated in space and time. GTP-exchange factors that activate small GTPases of the Rho family play an important role in this process. Here we review the role of this class of cytoskeletal regulators during important developmental processes such as epithelial morphogenesis, cytokinesis, cell migration, cell polarity, neuronal growth cone extension and phagocytosis in different model systems.

AB - The development of multicellular organisms is associated with extensive rearrangements of tissues and cell sheets. The driving force for these rearrangements is generated mostly by the actin cytoskeleton. In order to permit the reproducible development of a specific body plan, dynamic reorganization of the actin cytoskeleton must be precisely coordinated in space and time. GTP-exchange factors that activate small GTPases of the Rho family play an important role in this process. Here we review the role of this class of cytoskeletal regulators during important developmental processes such as epithelial morphogenesis, cytokinesis, cell migration, cell polarity, neuronal growth cone extension and phagocytosis in different model systems.

KW - cytokinesis

KW - morphogenesis

KW - RhoGEF

KW - myosin

KW - actin

KW - cytoskeleton

KW - GTPase

U2 - 10.4161/sgtp.1.1.12672

DO - 10.4161/sgtp.1.1.12672

M3 - Article

VL - 1

SP - 28

EP - 43

JO - Small GTPases

T2 - Small GTPases

JF - Small GTPases

SN - 2154-1248

IS - 1

ER -