RIFM fragrance ingredient safety assessment, 2-Methyl-3-buten-2-ol, CAS Registry Number 115-18-4.

Research output: Contribution to journalArticle

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose, developmental, and reproductive toxicities were determined to have the most conservative systemic exposure derived NO[A]EL of 50 mg/kg/day, based on OECD gavage toxicity studies in rats, that resulted in a MOE of 4545455 after considering 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

Details

Authors
  • A M Api
  • D Belsito
  • S Bhatia
  • P Calow
  • M L Dagli
  • W Dekant
  • A D Fryer
  • L Kromidas
  • S La Cava
  • J F Lalko
  • A Lapczynski
  • D C Liebler
  • Y Miyachi
  • V T Politano
  • G Ritacco
  • D Salvito
  • J Shen
  • T W Schultz
  • I G Sipes
  • B Wall
  • D K Wilcox
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology
Original languageEnglish
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Early online date2015 Jul 21
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes