RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5

Research output: Contribution to journalReview article


The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.


  • A M Api
  • D Belsito
  • D. Botelho
  • D. Browne
  • G. A. Burton
  • J. Buschmann
  • P. Calow
  • M L Dagli
  • M. Date
  • W. Dekant
  • C. Deodhar
  • A. D. Fryer
  • K. D. Joshi
  • S La Cava
  • A Lapczynski
  • D C Liebler
  • Kevin D. O'Brien
  • R. Parakhia
  • A. Patel
  • T. M. Penning
  • G Ritacco
  • J. Romine
  • D Salvito
  • T W Schultz
  • I G Sipes
  • Y. Thakkar
  • Shui Lung Tsang
  • J. Wahler
External organisations
  • Columbia University
  • Skåne University Hospital
  • University of Michigan
  • Fraunhofer Institute for Toxicology and Experimental Medicine
  • University of Minnesota system
  • University of São Paulo
  • Research Institute for Fragrance Materials, Inc.
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • University of Pennsylvania
  • University of Arizona
  • Vanderbilt University
  • University of Tennessee
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Environmental Health and Occupational Health


  • Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
Original languageEnglish
Pages (from-to)S234-S241
JournalFood and Chemical Toxicology
Issue numberSuppl. 1
Early online date2017 May 30
Publication statusPublished - 2017
Publication categoryResearch