RIFM fragrance ingredient safety assessment, allyl (cyclohexyloxy)acetate, CAS registry number 68901-15-5.

Research output: Contribution to journalArticle

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for Genotoxicity, Repeated Dose Toxicity, Developmental Toxicity, Reproductive Toxicity, Local Respiratory Toxicity, Phototoxicity, Skin Sensitization potential as well as Environmental assessment. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 7.5 mg/kg/day, based on a gavage reproduction dosage-range finding study conducted in rats on a read across analog, that resulted in a MOE of 441 considering 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

Details

Authors
  • A M Api
  • D Belsito
  • S Bhatia
  • P Calow
  • M L Dagli
  • W Dekant
  • A D Fryer
  • L Kromidas
  • S LA Cava
  • J F Lalko
  • A Lapczynski
  • D C Liebler
  • Y Miyachi
  • V T Politano
  • G Ritacco
  • D Salvito
  • J Shen
  • T W Schultz
  • I G Sipes
  • B Wall
  • D K Wilcox
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology
Original languageEnglish
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Early online date2015 Mar 26
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes