RIFM fragrance ingredient safety assessment, butyl 10-undecenoate, CAS Registry Number 109-42-2

Research output: Contribution to journalReview article

Abstract

Butyl 10-undecenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not expected to be genotoxic. Data on butyl 10-undecenoate and read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not a safety concern under the current, declared levels of use for the skin sensitization endpoint. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to butyl 10-undecenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; butyl 10-undecenoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; butyl 10-undecenoate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

Details

Authors
  • A. M. Api
  • D. Belsito
  • D. Botelho
  • G. A. Burton
  • J. Buschmann
  • M. L. Dagli
  • M. Date
  • W. Dekant
  • C. Deodhar
  • M. Francis
  • A. D. Fryer
  • L. Jones
  • K. Joshi
  • S. La Cava
  • A. Lapczynski
  • D. C. Liebler
  • D. O'Brien
  • A. Patel
  • T. M. Penning
  • G. Ritacco
  • J. Romine
  • N. Sadekar
  • D. Salvito
  • T. W. Schultz
  • I. G. Sipes
  • G. Sullivan
  • Y. Thakkar
  • Y. Tokura
  • S. Tsang
External organisations
  • Research Institute for Fragrance Materials, Inc.
  • Columbia University
  • Skåne University Hospital
  • University of Michigan
  • Fraunhofer Institute for Toxicology and Experimental Medicine
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • Vanderbilt University School of Medicine
  • University of Pennsylvania
  • University of Tennessee
  • University of Arizona
  • Hamamatsu University School of Medicine
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology
Original languageEnglish
Article number110619
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Volume130
Issue numberSuppl. 1
Publication statusPublished - 2019 Aug
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes