RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9

Research output: Contribution to journalArticle


Summary: The use of this material under current conditions is supported by existing information. The material (dihydro-β-terpinyl acetate) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the read across analog menthyl acetate (1α,2β,5α) (CAS # 89-48-5) show that dihydro-β- terpinyl acetate is not genotoxic nor does it have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated, dihydro-β-terpinyl acetate was found not to be PBT as per the IFRA Environmental Standards and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are <1.


  • A. M. Api
  • D. Belsito
  • D. Botelho
  • D. Browne
  • G. A. Burton
  • J. Buschmann
  • M. L. Dagli
  • M. Date
  • W. Dekant
  • C. Deodhar
  • M. Francis
  • A. D. Fryer
  • K. Joshi
  • S. La Cava
  • A. Lapczynski
  • D. C. Liebler
  • D. O'Brien
  • R. Parakhia
  • A. Patel
  • T. M. Penning
  • G. Ritacco
  • J. Romine
  • D. Salvito
  • T. W. Schultz
  • I. G. Sipes
  • Y. Thakkar
  • E. H. Theophilus
  • A. K. Tiethof
  • Y. Tokura
  • S. Tsang
  • J. Wahler
External organisations
  • Research Institute for Fragrance Materials, Inc.
  • Columbia University
  • Skåne University Hospital
  • University of Michigan
  • Fraunhofer Institute for Toxicology and Experimental Medicine
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • University of Pennsylvania
  • University of Tennessee
  • University of Arizona
  • Hamamatsu University School of Medicine
  • Vanderbilt University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology


  • Environmental safety, Local respiratory toxicity, Phototoxicity/photoallergencity, Repeated dose, developmental and reproductive toxicity, Skin sensitization
Original languageEnglish
JournalFood and Chemical Toxicology
Publication statusE-pub ahead of print - 2018 Feb 17
Publication categoryResearch
Externally publishedYes