RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

Research output: Contribution to journalArticle

Abstract

This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE> 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Details

Authors
  • A. M. Api
  • D. Belsito
  • S. Bhatia
  • P. Calow
  • M. L. Dagli
  • W. Dekant
  • A. D. Fryer
  • L. Kromidas
  • S. La Cava
  • A. Lapczynski
  • D. C. Liebler
  • D. O'Brien
  • R. Parakhia
  • T. M. Penning
  • V. T. Politano
  • G. Ritacco
  • D. Salvito
  • T. W. Schultz
  • J. Shen
  • I. G. Sipes
  • B. Wall
  • D. K. Wilcox
External organisations
  • Columbia University
  • Skåne University Hospital
  • University of Minnesota system
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • Vanderbilt University
  • University of Pennsylvania
  • University of Tennessee
  • University of Arizona
  • Research Institute for Fragrance Materials, Inc.
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology

Keywords

  • Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
Original languageEnglish
Pages (from-to)S1-S8
JournalFood and Chemical Toxicology
Volume110
Issue numberSuppl. 1
Early online date2016 Sep 27
Publication statusPublished - 2017
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes