RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

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RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9. / Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M.; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L.; La Cava, S.; Lapczynski, A.; Liebler, D. C.; O'Brien, D.; Parakhia, R.; Penning, T. M.; Politano, V. T.; Ritacco, G.; Salvito, D.; Schultz, T. W.; Shen, J.; Sipes, I. G.; Wall, B.; Wilcox, D. K.

In: Food and Chemical Toxicology, Vol. 110, No. Suppl. 1, 2017, p. S1-S8.

Research output: Contribution to journalArticle

Harvard

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lapczynski, A, Liebler, DC, O'Brien, D, Parakhia, R, Penning, TM, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2017, 'RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9', Food and Chemical Toxicology, vol. 110, no. Suppl. 1, pp. S1-S8. https://doi.org/10.1016/j.fct.2016.10.029

APA

CBE

Api AM, Belsito D, Bhatia S, Bruze M, Calow P, Dagli ML, Dekant W, Fryer AD, Kromidas L, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Parakhia R, Penning TM, Politano VT, Ritacco G, Salvito D, Schultz TW, Shen J, Sipes IG, Wall B, Wilcox DK. 2017. RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9. Food and Chemical Toxicology. 110(Suppl. 1):S1-S8. https://doi.org/10.1016/j.fct.2016.10.029

MLA

Vancouver

Author

Api, A. M. ; Belsito, D. ; Bhatia, S. ; Bruze, M. ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, A. D. ; Kromidas, L. ; La Cava, S. ; Lapczynski, A. ; Liebler, D. C. ; O'Brien, D. ; Parakhia, R. ; Penning, T. M. ; Politano, V. T. ; Ritacco, G. ; Salvito, D. ; Schultz, T. W. ; Shen, J. ; Sipes, I. G. ; Wall, B. ; Wilcox, D. K. / RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9. In: Food and Chemical Toxicology. 2017 ; Vol. 110, No. Suppl. 1. pp. S1-S8.

RIS

TY - JOUR

T1 - RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

AU - Api, A. M.

AU - Belsito, D.

AU - Bhatia, S.

AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, A. D.

AU - Kromidas, L.

AU - La Cava, S.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - O'Brien, D.

AU - Parakhia, R.

AU - Penning, T. M.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Shen, J.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

PY - 2017

Y1 - 2017

N2 - This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE> 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

AB - This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE> 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

KW - Developmental and reproductive toxicity

KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity/photoallergenicity

KW - Repeated dose

KW - Skin sensitization

UR - http://www.scopus.com/inward/record.url?scp=85006757043&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2016.10.029

DO - 10.1016/j.fct.2016.10.029

M3 - Article

VL - 110

SP - S1-S8

JO - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

T2 - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

SN - 1873-6351

IS - Suppl. 1

ER -