RIFM fragrance ingredient safety assessment, isoeugenol, CAS Registry Number 97-54-1.
Research output: Contribution to journal › Review article
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 37.5 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in mice resulted in a MOE of 5769 while considering 38.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association|
|Early online date||2015 Dec 23|
|Publication status||Published - 2016 Nov|