RIFM fragrance ingredient safety assessment, isoeugenol, CAS Registry Number 97-54-1.

Research output: Contribution to journalReview article

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 37.5 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in mice resulted in a MOE of 5769 while considering 38.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Details

Authors
  • A M Api
  • D Belsito
  • S Bhatia
  • P Calow
  • M L Dagli
  • W Dekant
  • A D Fryer
  • L Kromidas
  • S La Cava
  • J F Lalko
  • A Lapczynski
  • D C Liebler
  • Y Miyachi
  • V T Politano
  • G Ritacco
  • D Salvito
  • T W Schultz
  • J Shen
  • I G Sipes
  • B Wall
  • D K Wilcox
Organisations
External organisations
  • Research Institute for Fragrance Materials, Inc.
  • Columbia University
  • University of Minnesota system
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Environmental Health and Occupational Health
Original languageEnglish
Pages (from-to)S49–S56
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Volume97
Early online date2015 Dec 23
Publication statusPublished - 2016 Nov
Publication categoryResearch
Peer-reviewedYes