RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS Registry Number 78-37-5

Research output: Contribution to journalArticle

Abstract

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8) and cinnamic acid (CAS # 621-82-9) as suitable read across analogs, which provided a MOE > 100. The repeated dose toxicity endpoint was completed using data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Details

Authors
  • A. M. Api
  • D. Belsito
  • S. Bhatia
  • P. Calow
  • M. L. Dagli
  • W. Dekant
  • A. D. Fryer
  • L. Kromidas
  • S. La Cava
  • J. F. Lalko
  • A. Lapczynski
  • D. C. Liebler
  • T. M. Penning
  • V. T. Politano
  • G. Ritacco
  • D. Salvito
  • T. W. Schultz
  • J. Shen
  • I. G. Sipes
  • B. Wall
  • D. K. Wilcox
External organisations
  • Columbia University
  • Skåne University Hospital
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • Vanderbilt University
  • University of Pennsylvania
  • University of Tennessee
  • University of Arizona
  • Research Institute for Fragrance Materials, Inc.
  • University of Minnesota system
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Dermatology and Venereal Diseases
  • Pharmacology and Toxicology

Keywords

  • Developmental and reproductive toxicity, Environmental safety, Genotoxicit, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
Original languageEnglish
Pages (from-to)S110-S118
JournalFood and Chemical Toxicology
Volume97
Publication statusPublished - 2016 Nov 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes