RIFM fragrance ingredient safety assessment, methyl 2-nonenoate, CAS Registry Number 111-79-5

Research output: Contribution to journalArticle

Abstract

The existing information supports the use of this material as described in this safety assessment. Methyl 2-nonenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog ethyl trans-2,cis-4-decadienoate (CAS # 3025-30-7) show that methyl 2-nonenoate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to methyl 2-nonenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). Data from the target and read-across analog isobutyl-2-butenoate (CAS # 589-66-2) do not indicate the material is a sensitizer. The phototoxicity/photoallergenicity endpoints were evaluated based on data and UV spectra; methyl 2-nonenoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; methyl 2-nonenoate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

Details

Authors
  • A. M. Api
  • F. Belmonte
  • D. Belsito
  • D. Botelho
  • G. A. Burton
  • J. Buschmann
  • M. L. Dagli
  • M. Date
  • W. Dekant
  • C. Deodhar
  • A. D. Fryer
  • S. Gadhia
  • L. Jones
  • K. Joshi
  • S. La Cava
  • A. Lapczynski
  • M. Lavelle
  • D. C. Liebler
  • M. Na
  • D. O'Brien
  • T. M. Penning
  • G. Ritacco
  • J. Romine
  • N. Sadekar
  • D. Salvito
  • T. W. Schultz
  • I. G. Sipes
  • G. Sullivan
  • Y. Thakkar
  • Y. Tokura
  • S. Tsang
External organisations
  • Research Institute for Fragrance Materials, Inc.
  • Columbia University
  • Skåne University Hospital
  • University of Michigan
  • Fraunhofer Institute for Toxicology and Experimental Medicine
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • University of Pennsylvania
  • University of Tennessee
  • University of Arizona
  • Hamamatsu University School of Medicine
  • Vanderbilt University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology

Keywords

  • And reproductive toxicity, Developmental, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Repeated dose, developmental, and reproductive toxicity, Skin sensitization
Original languageEnglish
Article number110622
JournalFood and Chemical Toxicology
Publication statusE-pub ahead of print - 2019 Jun 22
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes