RIFM fragrance ingredient safety assessment, α-Methylbenzyl acetate, CAS Registry Number 93-92-5

Research output: Contribution to journalArticle

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Developmental toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 100 mg/kg/day. A gavage developmental toxicity study conducted in rats on a suitable read across analog resulted in aMOE of 3571 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Details

Authors
  • A. M. Api
  • D. Belsito
  • S. Bhatia
  • P. Calow
  • M. L. Dagli
  • W. Dekant
  • A. D. Fryer
  • L. Kromidas
  • S. La Cava
  • J. F. Lalko
  • A. Lapczynski
  • D. C. Liebler
  • V. T. Politano
  • G. Ritacco
  • D. Salvito
  • T. W. Schultz
  • J. Shen
  • I. G. Sipes
  • B. Wall
  • D. K. Wilcox
External organisations
  • Columbia University
  • Skåne University Hospital
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • Vanderbilt University
  • University of Tennessee
  • University of Arizona
  • Research Institute for Fragrance Materials, Inc.
  • University of Minnesota system
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology
  • Environmental Health and Occupational Health

Keywords

  • Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Reproductive and developmental toxicity, Skin sensitization
Original languageEnglish
Pages (from-to)S57-S68
Number of pages12
JournalFood and Chemical Toxicology
Volume97
Publication statusPublished - 2016 Nov 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes