RIFM fragrance ingredient safety assessment, p-Isopropylbenzyl acetate, CAS Registry Number 59230-57-8

Research output: Contribution to journalReview article

Abstract

The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog, benzyl acetate (CAS # 140-11-4), show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using benzyl acetate (CAS # 140-11-4) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Details

Authors
  • A. M. Api
  • D. Belsito
  • S. Bhatia
  • P. Calow
  • M. L. Dagli
  • W. Dekant
  • A. D. Fryer
  • L. Kromidas
  • S. La Cava
  • J. F. Lalko
  • A. Lapczynski
  • D. C. Liebler
  • V. T. Politano
  • G. Ritacco
  • D. Salvito
  • T. W. Schultz
  • J. Shen
  • I. G. Sipes
  • B. Wall
  • D. K. Wilcox
Organisations
External organisations
  • Research Institute for Fragrance Materials, Inc.
  • Columbia University
  • University of Minnesota system
  • University of São Paulo
  • Julius Maximilian University of Würzburg
  • Oregon Health & Science University
  • Vanderbilt University
  • University of Tennessee
  • University of Arizona
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Environmental Health and Occupational Health
  • Pharmacology and Toxicology

Keywords

  • Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, developmental and reproductive toxicity, Skin sensitization
Original languageEnglish
Pages (from-to)S69-S79
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Volume97
Issue numberSuppl.
Early online date2016 Mar 5
Publication statusPublished - 2016 Nov
Publication categoryResearch
Peer-reviewedYes