Risk factors for Clostridium difficile infection in the community: a case-control study in patients in general practice, Denmark, 2009-2011

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Bibtex

@article{7cb0538f90a1451f96695cda3a0447f5,
title = "Risk factors for Clostridium difficile infection in the community: a case-control study in patients in general practice, Denmark, 2009-2011",
abstract = "To identify risk factors for Clostridium difficile infection (CDI) in Danish patients consulting general practice with gastrointestinal symptoms, a prospective matched case-control study was performed; cases (N=259) had positive cultures for toxigenic C. difficile and controls (N=455) negative cultures. Data were analysed by conditional logistic regression. In patients aged 2 years (138 cases), hospitalization [odds ratio (OR) 84, 95{\%} confidence interval (CI) 31-23], consumption of beef (OR 55, 95{\%} CI 20-15), phenoxymethylpenicillin (OR 15, 95{\%} CI 27-82), dicloxacillin (OR 27, 95{\%} CI 36-211), and extended spectrum penicillins (OR 92, 95{\%} CI 19-45) were associated with CDI. In patients aged <2 years none of these were associated with CDI, but in a subgroup analysis contact with animals was associated with CDI (OR 81, 95{\%} CI 10-64). This study emphasizes narrow-spectrum penicillins, and suggests beef consumption, as risk factors for CDI in adults, and indicates a different epidemiology of CDI in infants.",
keywords = "Antibiotics, case-control study, children, community-associated, Clostridium difficile infection, zoonoses",
author = "Soes, {L. M.} and Holt, {H. M.} and Blenda B{\"o}ttiger and Nielsen, {H. V.} and V. Andreasen and M. Kemp and Olsen, {K. E. P.} and S. Ethelberg and K. Molbak",
year = "2014",
doi = "10.1017/S0950268813002380",
language = "English",
volume = "142",
pages = "1437--1448",
journal = "Epidemiology and Infection",
issn = "0950-2688",
publisher = "Cambridge University Press",
number = "7",

}