Risk factors for primary intracerebral hemorrhage: a population-based nested case-control study

Research output: Contribution to journalArticle

Standard

Risk factors for primary intracerebral hemorrhage : a population-based nested case-control study. / Zia, Elisabet; Pessah-Rasmussen, Hélène; Khan, Farhad Ali; Norrving, Bo; Janzon, Lars; Berglund, Göran; Engström, Gunnar.

In: Cerebrovascular Diseases, Vol. 21, No. 1-2, 2006, p. 18-25.

Research output: Contribution to journalArticle

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - Risk factors for primary intracerebral hemorrhage

T2 - Cerebrovascular Diseases

AU - Zia, Elisabet

AU - Pessah-Rasmussen, Hélène

AU - Khan, Farhad Ali

AU - Norrving, Bo

AU - Janzon, Lars

AU - Berglund, Göran

AU - Engström, Gunnar

N1 - Copyright (c) 2006 S. Karger AG, Basel.

PY - 2006

Y1 - 2006

N2 - PURPOSE: In this population-based study, risk factors for primary intracerebral hemorrhage (PICH) and PICH subtypes were explored in a nested case-control design.METHOD: Risk factors were determined in 22,444 men and 10,902 women (mean age 47 years) who participated in a health-screening programme between 1974 and 1991. 147 subjects with CT or autopsy-verified first-ever PICH during the follow-up period (mean 14 years) were compared with 1,029 stroke-free controls, matched for age, sex and screening-year.RESULTS: As compared to controls, PICH cases had significantly higher blood pressure (135/91 vs. 127/85 mm Hg), triglycerides (1.7 vs. 1.4 mmol/l), BMI (25.5 vs. 24.8) and shorter stature (1.73 vs. 1.74 m). Diabetes (6.9 vs. 2.8 %) and history of psychiatric morbidity (19.7 vs. 11.0 %) were more common in PICH cases and more of them were living alone (35.4 vs. 25.5%). After adjustment in a backward logistic regression model, high systolic blood pressure, diabetes, high triglycerides, short stature and psychiatric morbidity remained significantly associated with PICH. As compared to the control group, high systolic blood pressure was significantly associated both with nonlobar and lobar PICH. Diabetes and psychiatric morbidity were associated with nonlobar PICH. Smoking doubled the risk for lobar PICH, but was unrelated to nonlobar PICH.CONCLUSION: In this prospective population-based study, hypertension, diabetes, height, triglycerides and psychiatric morbidity were risk factors for PICH. Smoking was a risk factor for lobar PICH only.

AB - PURPOSE: In this population-based study, risk factors for primary intracerebral hemorrhage (PICH) and PICH subtypes were explored in a nested case-control design.METHOD: Risk factors were determined in 22,444 men and 10,902 women (mean age 47 years) who participated in a health-screening programme between 1974 and 1991. 147 subjects with CT or autopsy-verified first-ever PICH during the follow-up period (mean 14 years) were compared with 1,029 stroke-free controls, matched for age, sex and screening-year.RESULTS: As compared to controls, PICH cases had significantly higher blood pressure (135/91 vs. 127/85 mm Hg), triglycerides (1.7 vs. 1.4 mmol/l), BMI (25.5 vs. 24.8) and shorter stature (1.73 vs. 1.74 m). Diabetes (6.9 vs. 2.8 %) and history of psychiatric morbidity (19.7 vs. 11.0 %) were more common in PICH cases and more of them were living alone (35.4 vs. 25.5%). After adjustment in a backward logistic regression model, high systolic blood pressure, diabetes, high triglycerides, short stature and psychiatric morbidity remained significantly associated with PICH. As compared to the control group, high systolic blood pressure was significantly associated both with nonlobar and lobar PICH. Diabetes and psychiatric morbidity were associated with nonlobar PICH. Smoking doubled the risk for lobar PICH, but was unrelated to nonlobar PICH.CONCLUSION: In this prospective population-based study, hypertension, diabetes, height, triglycerides and psychiatric morbidity were risk factors for PICH. Smoking was a risk factor for lobar PICH only.

KW - Adult

KW - Body Height

KW - Case-Control Studies

KW - Cerebral Hemorrhage

KW - Cohort Studies

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Hyperlipidemias

KW - Hypertension

KW - Life Style

KW - Male

KW - Marital Status

KW - Mental Disorders

KW - Middle Aged

KW - Risk Factors

KW - Sweden

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1159/000089589

DO - 10.1159/000089589

M3 - Article

VL - 21

SP - 18

EP - 25

JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

SN - 1421-9786

IS - 1-2

ER -