Ru-Catalyzed Cross-Dehydrogenative Coupling between Primary Alcohols to Guerbet Alcohol Derivatives: With Relevance for Fragrance Synthesis

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Ru-Catalyzed Cross-Dehydrogenative Coupling between Primary Alcohols to Guerbet Alcohol Derivatives : With Relevance for Fragrance Synthesis. / Manojveer, Seetharaman; Salahi, Saleh; Wendt, Ola F.; Johnson, Magnus T.

In: Journal of Organic Chemistry, Vol. 83, No. 18, 2018, p. 10864-10870.

Research output: Contribution to journalArticle

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TY - JOUR

T1 - Ru-Catalyzed Cross-Dehydrogenative Coupling between Primary Alcohols to Guerbet Alcohol Derivatives

T2 - With Relevance for Fragrance Synthesis

AU - Manojveer, Seetharaman

AU - Salahi, Saleh

AU - Wendt, Ola F.

AU - Johnson, Magnus T.

PY - 2018

Y1 - 2018

N2 - A simple method has been developed for the cross dehydrogenative coupling between two different primary alcohols using readily available RuCl2(PPh3)3 as a precatalyst through the borrowing-hydrogen approach. The present methodology is applicable to a large variety of alcohol derivatives including long chain aliphatic alcohols and heteroaryl alcohols. In addition, the methodology was applied in a straightforward protocol to synthesize commercially available fragrances such as Rosaphen and Cyclamenaldehyde in good yields.

AB - A simple method has been developed for the cross dehydrogenative coupling between two different primary alcohols using readily available RuCl2(PPh3)3 as a precatalyst through the borrowing-hydrogen approach. The present methodology is applicable to a large variety of alcohol derivatives including long chain aliphatic alcohols and heteroaryl alcohols. In addition, the methodology was applied in a straightforward protocol to synthesize commercially available fragrances such as Rosaphen and Cyclamenaldehyde in good yields.

U2 - 10.1021/acs.joc.8b01558

DO - 10.1021/acs.joc.8b01558

M3 - Article

C2 - 30091596

AN - SCOPUS:85052320561

VL - 83

SP - 10864

EP - 10870

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 1520-6904

IS - 18

ER -